AbstractResident doctors often suffer from stress and anxiety due to the nature of long, stressful work hours within hospital environments. One influential factor is being away from natural environments within hospital environments. This paper explores interior design, focusing on the intrusion of biophilic design and its impact on resident doctors’ well-being and stress levels. A mixed-methods approach and a concurrent triangulation design were used to collect quantitative data to test the hypothesis and qualitative data to provide context and a foundation for situating and explaining the quantitative results. This methodology includes a photographic survey, observation, questionnaire, and VR experiment. The result of this paper is shown to confirm the effect of biophilic design elements within the hospital environment and their impact on enhancing the well-being of residents and reducing their stress levels. There is a need for more research on the internal environment of hospitals and their strengthening through biophilic design. This study provides insights into the well-being and stress levels of resident doctors related to the nature of the internal environment within the hospital.